Abstract | BACKGROUND: METHODS: RESULTS: Significant increases were demonstrated in both blood βHB levels and the number of seconds required before isoflurane-induced anesthesia (immobility) after the final treatment by all exogenous ketone supplements. Moreover, this effect of exogenous ketone supplements positively correlated with blood βHB levels. It was also demonstrated that DPCPX completely abolished the effect of KEKS on isoflurane-induced anesthesia (time until immobility), but not SCH 58261. CONCLUSIONS: These findings strengthen our previous suggestion that exogenous ketone supplements may modulate the isoflurane-induced onset of anesthesia (immobility), likely through A1Rs.
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Authors | Zsolt Kovács, Brigitta Brunner, Dominic P D'Agostino, Csilla Ari |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 20
Issue 1
Pg. 30
(01 30 2020)
ISSN: 1471-2253 [Electronic] England |
PMID | 32000673
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adenosine A1 Receptor Antagonists
- Anesthetics, Inhalation
- Ketones
- Isoflurane
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Topics |
- Adenosine A1 Receptor Antagonists
(administration & dosage)
- Anesthesia
(methods)
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Disease Models, Animal
- Isoflurane
(pharmacology)
- Ketones
(pharmacology)
- Ketosis
(blood, physiopathology)
- Male
- Time
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