Abstract | OBJECTIVE/HYPOTHESIS: STUDY DESIGN: Prospective, double-blind, randomized controlled trial. METHODS: One hundred forty patients aged 3 to 7 years undergoing tonsillectomy were divided into two groups. Fentanyl (1 μg/kg) was administered at the end of surgery in group 1 (n = 70) and at 10 to 15 minutes before the end of surgery in group 2 (n = 70). Time to regular breathing and time to emergence from anesthesia were measured from the end of surgery. PONV and pediatric anesthesia emergence delirium scale scores were assessed every 10 minutes after admission to the postanesthesia care unit. RESULTS: Incidences of PONV (2.9% vs. 2.9%, P > .99) and emergence delirium (11.4% vs. 5.7%, P = .23) were not significantly different between the two groups. Time to regular breathing (mean difference = 2.3 minutes; 95% confidence interval [CI]: 0.9 to 3.7 minutes) and time to emergence (median difference = 6.5 minutes; 95% CI, 2.5 to 10.5 minutes) were significantly longer in group 1 than in group 2. CONCLUSIONS: Although there was no beneficial effect on PONV, recovery of regular breathing and consciousness was quicker with earlier fentanyl administration. Emergence delirium was well-controlled, similar to that with fentanyl administration at the end of surgery. LEVEL OF EVIDENCE:
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Authors | Hye Jin Kim, Min-Soo Kim, Ha Yan Kim, Wyun Kon Park, Won Shik Kim, Sungmi Kim, Hyun Joo Kim |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 130
Issue 12
Pg. 2900-2905
(12 2020)
ISSN: 1531-4995 [Electronic] United States |
PMID | 31985080
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2020 The American Laryngological, Rhinological and Otological Society, Inc. |
Chemical References |
- Analgesics, Opioid
- Fentanyl
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Topics |
- Analgesics, Opioid
(administration & dosage)
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Fentanyl
(administration & dosage)
- Humans
- Infusions, Intravenous
- Male
- Pain, Postoperative
(prevention & control)
- Postoperative Nausea and Vomiting
(epidemiology)
- Prospective Studies
- Tonsillectomy
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