Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases.

Abstract

Autophagy is a cellular process that degrades intracellular components, including misfolded proteins and damaged organelles. Many neurodegenerative diseases are considered to progress via the accumulation of misfolded proteins and damaged organelles; therefore, autophagy functions in regulating disease severity. There are at least two types of autophagy (canonical autophagy and alternative autophagy), and canonical autophagy has been applied to therapeutic strategies against various types of neurodegenerative diseases. In contrast, the role of alternative autophagy has not yet been clarified, but it is speculated to be involved in the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease.

• Authors: Shinya Honda, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hajime Tajima Sakurai, Masatsune Tsujioka, Michiko Murohashi, Shigeomi Shimizu
• Journal: Journal of molecular biology (J Mol Biol) Vol. 432 Issue 8 Pg. 2622-2632 (04 03 2020) ISSN: 1089-8638 [Electronic] Netherlands
• PMID: 31978398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Autophagy-Related Protein 5

Topics

• Animals
• Autophagy
• Autophagy-Related Protein 5 (metabolism)
• Humans
• Neurodegenerative Diseases (metabolism, pathology)