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Mutations in the hemagglutinin gene associated with influenza virus resistance to norakin.

Abstract
The nucleotide sequences of the hemagglutinin genes of four norakin-resistant mutants of Influenza A/FPV/Weybridge were determined and compared to the wild-type hemagglutinin. All mutants show one or two amino acid substitutions which are discussed to destabilise the pH 7 conformation of hemagglutinin.
AuthorsS Prösch, H Heider, C Schroeder, D H Krüger
JournalArchives of virology (Arch Virol) Vol. 102 Issue 1-2 Pg. 125-9 ( 1988) ISSN: 0304-8608 [Print] Austria
PMID3196166 (Publication Type: Journal Article)
Chemical References
  • Hemagglutinins, Viral
  • Piperidines
  • triperiden
Topics
  • Amino Acid Sequence
  • Drug Resistance, Microbial
  • Genes, Viral
  • Hemagglutinins, Viral (genetics)
  • Influenza A virus (drug effects, genetics)
  • Piperidines (pharmacology)
  • Structure-Activity Relationship

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