Abstract | BACKGROUND: METHODS: Information regarding gene mutations and patients' survival time in advanced LUAD was downloaded from The Cancer Genome Atlas (TCGA) database. The diversity of TMB in different EGFR-mutant types was observed and the predicted value of TMB for OS as well as other co-mutations were analyzed. The diversity of TMB was also observed in another Chinese cohort of advanced LUAD patients. RESULTS: The median TMB values of EGFR wild-type, other types of EGFR mutations, exon 19 deletions and L858R were 6.12, 5.66, 3.77 and 4.72, differences between wild-type and EGFR sensitive mutations (exon 19 deletion or L858R) were significant (P<0.001 and P<0.01). OS time of high TMB group was inferior to that of the low TMB group (24.03 months vs. not reached, P=0.0020). TMB and TP53 together will make more accurate prediction of OS in EGFR-mutant advanced LUAD patients. Distribution of TMB in another Chinese cohort had the same trend. CONCLUSIONS: In advanced LUAD patients, TMB was lower in patients with EGFR-mutant group than EGFR wild group. TMB was a negative prognostic biomarker of OS in EGFR-mutant LUAD patients, especially when TP53 was mutated together.
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Authors | Xiao-Dong Jiao, Xi He, Bao-Dong Qin, Ke Liu, Ying Wu, Jun Liu, Ting Hou, Yuan-Sheng Zang |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 11
Issue 11
Pg. 4507-4515
(Nov 2019)
ISSN: 2072-1439 [Print] China |
PMID | 31903239
(Publication Type: Journal Article)
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Copyright | 2019 Journal of Thoracic Disease. All rights reserved. |