Abstract | BACKGROUND: PATIENTS AND METHODS:
Breast cancer patients who received 260 mg/m2 of nab-PTX were eligible to participate in this trial. Patients wore a FG on one hand (60 min) without changing and two SGs of the same size (i.e., one size smaller than the size that best fit their hand) on the other hand (90 min) during chemotherapy. Peripheral neuropathy was evaluated at each treatment cycle using Common Terminology Criteria for Adverse Events (CTCAE) version 4.0, the Patient Neurotoxicity Questionnaire (PNQ), and the Functional Assessment of Cancer Therapy- Taxane subscale. Temperatures at each fingertip in both groups were measured thermographically. RESULTS: Between August 2017 and March 2019, 43 patients were enrolled and 38 were evaluated. No cases showed discordance of peripheral neuropathy between each gloved group in cases of CTCAE ≥ grade 2. In cases of PNQ ≥ grade D, using the Nam equivalence test, the upper test (P = 0.0329) and lower test (P = 0.0052) both showed negative results in comparisons between each gloved group. Fingertip temperature was significantly lower in the FG group than in the SG group after treatment (P < 0.0001). CONCLUSIONS:
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Authors | Yuko Kanbayashi, Koichi Sakaguchi, Takeshi Ishikawa, Yoshimi Ouchi, Katsuhiko Nakatsukasa, Yusuke Tabuchi, Fuminao Kanehisa, Minako Hiramatsu, Ryo Takagi, Isao Yokota, Norito Katoh, Tetsuya Taguchi |
Journal | Breast (Edinburgh, Scotland)
(Breast)
Vol. 49
Pg. 219-224
(Feb 2020)
ISSN: 1532-3080 [Electronic] Netherlands |
PMID | 31901783
(Publication Type: Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2019 Elsevier Ltd. All rights reserved. |
Chemical References |
- 130-nm albumin-bound paclitaxel
- Albumins
- Antineoplastic Agents, Phytogenic
- Paclitaxel
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Albumins
(adverse effects, therapeutic use)
- Antineoplastic Agents, Phytogenic
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Combined Modality Therapy
- Compression Bandages
- Cryotherapy
- Female
- Humans
- Middle Aged
- Paclitaxel
(adverse effects, therapeutic use)
- Peripheral Nervous System Diseases
(chemically induced, prevention & control)
- Prospective Studies
- Treatment Outcome
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