Cervical lymph node metastasis of ovarian dysgerminoma: A case report with fine needle aspiration cytology.

Abstract

Dysgerminoma is a rare germ cell tumor, accounting for 1% to 2% of all malignant ovarian tumors. Here, we report a case of dysgerminoma diagnosed by aspiration cytology of a cervical lymph node. A 20-year-old woman presented with an abdominal mass and left cervical swelling. CT revealed a large pelvic tumor, along with a nodular lesion on the left side of neck. Fine needle aspiration (FNA) cytology of a cervical lymph node showed large atypical cells and small lymphocytes. Immunocytochemical staining on cell block material revealed that these large tumor cells were positive for placental alkaline phosphatase, D2-40, and c-kit. Dysgerminoma was suggested by FNA cytology. Furthermore, bilateral oophorectomy was performed, and histology confirmed the diagnosis of ovarian dysgerminoma. FNA cytology of metastatic lymph nodes along with immunocytochemistry is a useful tool for diagnosis of dysgerminoma.

• Authors: Kazunari Maekawa, Takako Tokumitsu, Eiko Minematsu, Hiroshi Noguchi, Eriko Nakamura, Yujiro Asada, Tetsuo Nakayama, Hiroshi Sameshima, Yuichiro Sato
• Journal: Diagnostic cytopathology (Diagn Cytopathol) Vol. 48 Issue 4 Pg. 356-359 (Apr 2020) ISSN: 1097-0339 [Electronic] United States
• PMID: 31886634 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2019 Wiley Periodicals, Inc.

Topics

• Adult
• Biopsy, Fine-Needle
• Dysgerminoma (diagnosis, metabolism, pathology, surgery)
• Female
• Humans
• Lymph Nodes (metabolism, pathology, surgery)
• Lymphatic Metastasis
• Ovarian Neoplasms (diagnosis, metabolism, pathology, surgery)