Malignancies in Patients with IgG4-Related Diseases in Head and Neck Regions.

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized disease, characterized by high serum IgG4 concentrations and IgG4-producing plasma cell expansion with fibrotic or sclerotic changes in affected organs. Recent work has focused on the relationship between IgG4-RD and malignancies, but there is no report of malignancies associated with IgG4-RD in head and neck regions. The aim of this study was to analyze the clinicopathological characteristics of malignancies in patients with IgG4-RD in head and neck regions. We retrospectively analyzed 26 patients with IgG4-RD (12 men and 14 women aged 60.6 ± 11.6 years). The mean follow-up period was 26.6 months (from 12 to 96 months). These patients were divided into single-lesion group (n = 12) with IgG4-RD only in head and neck regions and multiple-lesion group (n = 14) with IgG4-RD in other regions. There was no significant difference in serum IgG4 concentrations between the single-lesion group (459.4 ± 336.4 mg/dL) and the multiple-lesion group (908.0 ± 739.2 mg/dL) (P = 0.07), whereas the IgG4/IgG ratio was significantly lower in the single-lesion group (22.8 ± 11.0%; n = 11) compared with the multiple-lesion group (31.7 ± 15.0%; n = 11, P = 0.02). Among the 26 patients, two patients (7.7%), both in the multiple-lesion group, developed life-threatening malignancies (salivary duct carcinoma in the submandibular gland and lymphoma in the orbital tissue). All physicians need to keep in mind the possible coexistence of malignancies in patients with IgG4-RD with high IgG4/IgG ratio and multiple lesions at the time of diagnosis.

• Authors: Ryoukichi Ikeda, Kazuya Kurakami, Nobuo Ohta, Takahiro Suzuki, Yutaro Saito, Yusuke Kusano, Muneharu Yamazaki, Yutaka Tateda, Shiori Kitaya, Seiji Kakehata, Hidetoshi Takahashi, Kennichi Satoh
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 249 Issue 4 Pg. 285-290 (12 2019) ISSN: 1349-3329 [Electronic] Japan
• PMID: 31875582 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Head and Neck Neoplasms (blood, complications, diagnostic imaging, pathology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin G4-Related Disease (blood, complications, diagnostic imaging, pathology)
• Male
• Middle Aged