Prolonged survival time of sarcoma 180-bearing mice treated with lipid microspheres-entrapped antitumor marine coral prostanoids.

Abstract

Antitumor marine coral prostanoids (clavulone II and chlorovulone I) were entrapped into lipid microspheres of 0.2 micron diameter to make lipo-drugs. Daily treatment with lipo-chlorovulone I (1.6 mg/kg/day, i.p.) and lipo-clavulone II (12.5 mg/kg/day, i.p.) on days 1 through 5 markedly prolonged the survival time (135% ILS and 73% ILS, respectively) of mice inoculated with sarcoma 180 as compared with that of a corresponding dose of respective free chlorovulone I and clavulone II. These results suggest that lipid microspheres may be used as drug delivery carriers for antitumor coral prostanoids in vivo.

• Authors: A Honda, Y Mori, Y Yamada, S Nakaike, H Hayashi, S Otomo
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 61 Issue 3 Pg. 413-6 (Sep 1988) ISSN: 0034-5164 [Print] United States
• PMID: 3187200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Lipids
• Prostaglandins A
• chlorovulone I
• clavulone II

Topics

• Animals
• Drug Carriers
• Lipids
• Male
• Mice
• Mice, Inbred ICR
• Microspheres
• Prostaglandins A (administration & dosage)
• Sarcoma 180 (drug therapy)