18F-FDG PET/CT Uptake Classification in Lymphoma and Lung Cancer by Using Deep Convolutional Neural Networks.

Abstract

Background Fluorine 18 (18F)-fluorodeoxyglucose (FDG) PET/CT is a routine tool for staging patients with lymphoma and lung cancer. Purpose To evaluate configurations of deep convolutional neural networks (CNNs) to localize and classify uptake patterns of whole-body 18F-FDG PET/CT images in patients with lung cancer and lymphoma. Materials and Methods This was a retrospective analysis of consecutive patients with lung cancer or lymphoma referred to a single center from August 2011 to August 2013. Two nuclear medicine experts manually delineated foci with increased 18F-FDG uptake, specified the anatomic location, and classified these findings as suspicious for tumor or metastasis or nonsuspicious. By using these expert readings as the reference standard, a CNN was developed to detect foci positive for 18F-FDG uptake, predict the anatomic location, and determine the expert classification. Examinations were divided into independent training (60%), validation (20%), and test (20%) subsets. Results This study included 629 patients (mean age, 52.2 years ± 20.4 [standard deviation]; 394 men). There were 302 patients with lung cancer and 327 patients with lymphoma. For the test set (123 patients; 10 782 foci), the CNN areas under the receiver operating characteristic curve (AUCs) for determining hypermetabolic 18F-FDG PET/CT foci that were suspicious for cancer versus nonsuspicious by using the five input features were as follows: CT alone, 0.78 (95% confidence interval [CI]: 0.72, 0.83); 18F-FDG PET alone, 0.97 (95% CI: 0.97, 0.98); 18F-FDG PET/CT, 0.98 (95% CI: 0.97, 0.99); 18F-FDG PET/CT maximum intensity projection (MIP), 0.98 (95% CI: 0.98, 0.99); and 18F-FDG PET/CT MIP atlas, 0.99 (95% CI: 0.98, 1.00). The combination of 18F-FDG PET and CT information improved overall classification accuracy (AUC, 0.975 vs 0.981, respectively; P < .001). Anatomic localization accuracy of the CNN was 2543 of 2639 (96.4%; 95% CI: 95.5%, 97.1%) for body part, 2292 of 2639 (86.9%; 95% CI: 85.3%, 88.5%) for region (ie, organ), and 2149 of 2639 (81.4%; 95% CI: 79.3%-83.5%) for subregion. Conclusion The fully automated anatomic localization and classification of fluorine 18-fluorodeoxyglucose PET uptake patterns in foci suspicious and nonsuspicious for cancer in patients with lung cancer and lymphoma by using a convolutional neural network is feasible and achieves high diagnostic performance when both CT and PET images are used. © RSNA, 2019 Online supplemental material is available for this article. See also the editorial by Froelich and Salavati in this issue.

• Authors: Ludovic Sibille, Robert Seifert, Nemanja Avramovic, Thomas Vehren, Bruce Spottiswoode, Sven Zuehlsdorff, Michael Schäfers
• Journal: Radiology (Radiology) Vol. 294 Issue 2 Pg. 445-452 (Feb 2020) ISSN: 1527-1315 [Electronic] United States
• PMID: 31821122 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Adult
• Female
• Fluorodeoxyglucose F18
• Humans
• Image Interpretation, Computer-Assisted (methods)
• Lung (diagnostic imaging, pathology)
• Lung Neoplasms (diagnostic imaging, pathology)
• Lymphoma (diagnostic imaging, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Neural Networks, Computer
• Positron Emission Tomography Computed Tomography (methods)
• Radiopharmaceuticals
• Retrospective Studies