Metabolome-Wide Association Study of Deployment to Balad, Iraq or Bagram, Afghanistan.

Abstract

OBJECTIVE:

To use high-resolution metabolomics (HRM) to identify metabolic changes in military personnel associated with deployment to Balad, Iraq, or Bagram, Afghanistan.

METHODS:

Pre- and post-deployment samples were obtained from the Department of Defense Serum Repository (DoDSR). HRM and bioinformatics were used to identify metabolic differences associated with deployment.

RESULTS:

Differences at baseline (pre-deployment) between personnel deployed to Bagram compared with Balad or Controls included sex hormone and keratan sulfate metabolism. Deployment to Balad was associated with alterations to amino acid and lipid metabolism, consistent with inflammation and oxidative stress, and pathways linked to metabolic adaptation and repair. Difference associated with deployment to Bagram included lipid pathways linked to cell signaling and inflammation.

CONCLUSIONS:

Metabolic variations in pre- and post-deployment are consistent with deployment-associated responses to air pollution and other environmental stressors.

• Authors: Young-Mi Go, Matthew R Smith, Douglas I Walker, Karan Uppal, Patricia Rohrbeck, Pamela L Krahl, Philip K Hopke, Mark J Utell, Timothy M Mallon, Dean P Jones
• Journal: Journal of occupational and environmental medicine (J Occup Environ Med) Vol. 61 Suppl 12 Pg. S25-S34 (12 2019) ISSN: 1536-5948 [Electronic] United States
• PMID: 31800448 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Environmental Pollutants

Topics

• Afghan Campaign 2001-
• Case-Control Studies
• Chromatography, High Pressure Liquid
• Environmental Exposure (statistics & numerical data)
• Environmental Pollutants (blood)
• Female
• Humans
• Inhalation Exposure (statistics & numerical data)
• Male
• Mass Spectrometry
• Metabolomics (statistics & numerical data)
• Military Personnel (statistics & numerical data)
• United States