Breast cancer is the most common
malignant neoplasm in women worldwide, and the treatment regimens currently available are far from optimal. Targeted
therapy, based on molecular typing of
breast cancer, is the most precise form of treatment, and
CXC chemokine receptor 2 (CXCR2) is one of the molecular markers used in targeted
therapies. As a member of the
seven transmembrane G-protein-coupled receptor family, CXCR2 and its associated
ligands have been increasingly implicated in
tumor-associated processes. These processes include proliferation, angiogenesis, invasion,
metastasis, chemoresistance, and stemness and phenotypic maintenance of cancer stem cells. Thus, the inhibition of CXCR2 or its downstream signaling pathways could significantly attenuate
tumor progression. Therefore, studies on the
biological functions of CXCR2 and its association with
neoplasia may help improve the prognosis of
breast cancer. Furthermore, the targeting of CXCR2 could supplement the present clinical approaches of
breast cancer treatment strategies. The present review discusses the structures and mechanisms of CXCR2 and its
ligands. Additionally, the contribution of CXCR2 to the development of
breast cancer and its potential therapeutic benefits are also discussed.