Abstract | AIM: METHODS: To assess 14 patients with an aldosterone-producing tumour, hyperglycaemic and hyperinsulinaemic-euglycaemic clamp tests as well as oral glucose tolerance tests (OGTTs) were performed before and after tumour excision. Time between presurgical analysis and surgery was 27-559 (194±132) days, and 14-142 (51±38) days between surgery and postsurgical analysis. Various parameters related to insulin secretion or sensitivity as determined by OGTT as well as hyperglycaemic and hyperinsulinaemic-euglycaemic clamp analyses were evaluated. RESULTS: Surgical treatment of tumours ameliorated hypokalaemia and reduced plasma aldosterone levels. First and second phases of insulin secretion during the hyperglycaemic clamp, as well as the insulinogenic index and total insulin secretion measured during OGTT, were also improved after surgery. In addition, the insulin sensitivity index determined during the hyperinsulinaemic-euglycaemic clamp was reduced after surgery. CONCLUSION:
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Authors | H Komada, Y Hirota, A So, T Nakamura, Y Okuno, H Fukuoka, G Iguchi, Y Takahashi, K Sakaguchi, W Ogawa |
Journal | Diabetes & metabolism
(Diabetes Metab)
Vol. 46
Issue 3
Pg. 236-242
(06 2020)
ISSN: 1878-1780 [Electronic] France |
PMID | 31676325
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Insulin
- hemoglobin A1c protein, human
- Aldosterone
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Topics |
- Adrenal Cortex Neoplasms
(blood, complications, surgery)
- Adrenocortical Adenoma
(blood, complications, surgery)
- Adult
- Aged
- Aldosterone
(blood)
- Blood Glucose
(analysis)
- Female
- Glucose Clamp Technique
- Glucose Tolerance Test
- Glycated Hemoglobin
(analysis)
- Humans
- Hyperaldosteronism
(blood, etiology, surgery)
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Insulin Secretion
(physiology)
- Male
- Middle Aged
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