Abstract | BACKGROUND: METHODS: This is a prospective observational cohort study. A total of 473 HD patients referred for the angioplasty of vascular access were enrolled. There were 190 arteriovenous grafts (AVG) and 283 arteriovenous fistulas (AVF). The follow-up lasted for 2 years after the interventions. Seven single nucleotide polymorphisms (SNPs) in DDAH1 were genotyped and ADMA were measured at baseline. The primary outcome was restenosis after angioplasty. RESULTS: Among the 7 SNPs, plasma ADMA levels were significantly different in DDAH1 rs233112 (GA + GG vs. AA, 0.86 ± 0.23 vs. 0.82 ± 0.19 μM, p = 0.03) and rs1498373 (CT + TT vs. CC, 0.87 ± 0.23 vs. 0.82 ± 0.20 μM, p = 0.02) genotypes. The AVF group with GG + GA genotype of rs233112 and CT + TT genotype of rs1498373 had higher risks of early restenosis at 3 months. In the AVG group, only GG + GA genotype of rs233112 was associated with early restenosis. A combined analysis of AVG and AVF groups showed that patients with rs233112 GA + GG genotype and rs1498373 CT + TT genotype had higher risks of early restenosis (both p < 0.001). The multivariate analysis results showed that the association of these genotypes with early restenosis is independent of clinical, access, or biochemical factors. CONCLUSIONS: Our findings suggest that certain DDAH1 polymorphisms modulate circulating ADMA levels and are associated with venous intimal hyperplasia.
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Authors | Chih-Cheng Wu, Mu-Yang Hsieh, Chih-Kuo Lee, Shao-Yuan Chuang, Ming-Yi Chung, Chih-Ching Lin |
Journal | American journal of nephrology
(Am J Nephrol)
Vol. 50
Issue 6
Pg. 454-464
( 2019)
ISSN: 1421-9670 [Electronic] Switzerland |
PMID | 31639806
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 S. Karger AG, Basel. |
Chemical References |
- N,N-dimethylarginine
- Arginine
- Amidohydrolases
- dimethylargininase
|
Topics |
- Aged
- Aged, 80 and over
- Amidohydrolases
(genetics, metabolism)
- Arginine
(analogs & derivatives, blood, metabolism)
- Arteriovenous Shunt, Surgical
(adverse effects)
- Female
- Follow-Up Studies
- Graft Occlusion, Vascular
(blood, epidemiology, genetics, pathology)
- Humans
- Hyperplasia
(genetics, pathology, surgery)
- Kidney Failure, Chronic
(therapy)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prospective Studies
- Renal Dialysis
(adverse effects)
- Tunica Intima
(pathology)
- Veins
(pathology)
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