Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats.

Abstract

Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction.

• Authors: Reza Arezoomandan, Abbas Aliaghaei, Fariba Khodagholi, Abbas Haghparast
• Journal: Asian journal of psychiatry (Asian J Psychiatr) Vol. 46 Pg. 70-73 (Dec 2019) ISSN: 1876-2026 [Electronic] Netherlands
• PMID: 31630007 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Excitatory Amino Acid Transporter 2
• Slc1a2 protein, rat
• Morphine
• Minocycline

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Behavior, Animal (drug effects)
• Disease Models, Animal
• Excitatory Amino Acid Transporter 2 (drug effects)
• Minocycline (pharmacology)
• Morphine
• Nucleus Accumbens (drug effects)
• Opioid-Related Disorders (drug therapy)
• Rats