The present study was undertaken to examine the
lipid spectrum of erythrocytic membranes and serum in children and adolescents with
type 1 diabetes mellitus (DM-1) during pathogenetic
therapy in relation to the duration of the disease, its severity, and the presence of vascular events. Ninety-nine patients with DM-1 and 40 healthy children of the same age were examined. The patients were on basic bolus
insulin therapy. In children, DM-1 was ascertained to be accompanied by not only atherogenic serum
lipid metabolic disturbances (the elevated levels of total
cholesterol,
triglycerides, low- and
very low-density lipoprotein cholesterol), but also by the impaired
lipid spectrum of erythrocytic membranes (reductions in the level of total
lipids and the fraction of
phosphatidylcholine (PC) with an increase in the level of fractions of tysophosphatidylcholine and phosphaUdylinositol; elevated levels of
saturated fatty acids and decreased levels of
unsaturated fatty acids in the fractions of PC and phosphatidylethanolamlne; the enhanced microviscosity of deep membranous layers and the modified outer membranous ones). Complex basic
therapy resulted in incomplete normalization of the study parameters of the
lipid spectrum of serum and erythrocytic membranes in DM complicated by microangiopathies, which requires optimization of conventional therapeutic regimens.