Prevalence and Risk Factors of Preoperative Deep Vein Thrombosis in Patients with End-Stage Knee Osteoarthritis.

Abstract

BACKGROUND:

The purpose of this study is to determine the prevalence and the risk factors of DVT in end-stage OA patients.

METHODS:

From March 2015 to June 2017, 521 patients with knee degenerative osteoarthritis undergoing knee arthroplasty were enrolled; 458 patients (87.9%) were admitted for primary total knee arthroplasty and 63 patients (12.1%) were admitted for unicompartmental knee arthroplasty. Parameters were compared using χ2 or t-test for both the groups. Binary logistic regression analysis was used to determine risk factors.

RESULTS:

The incidence of preoperative DVT was 6.7% (n = 35). Age in preoperative DVT group was significantly more than the non-DVT group (72.54 ± 6.53 vs. 68.65 ± 7.35, P = 0.002). Preoperative D-dimer >0.5 μg/mL (P < 0.001) was also associated with preoperative DVT in knee osteoarthritis patients. The incidence increased with age significantly (2.17% in <65 years, 6.86% in ≥65 <75 years, and 12.26% in ≥75 years) (P = 0.008). Thus, age (P = 0.041, OR 1.075, 95% CI [1.002-1.110]) and D-dimer >0.5 μg/mL (P < 0.001, OR 4.441, 95% CI [1.942-10.153]) were the independent risk factors for preoperative DVT in knee osteoarthritis patients.

CONCLUSIONS:

The incidence of DVT in end-stage osteoarthritis was 6.7%. The results suggest that older people aged over 75 and D-dimer > 0.5 μg/mL were risk factors for DVT among patients admitted to the hospital for total knee arthroplasty. Instrumental screening should be encouraged, especially in subgroups at higher risk for preoperative DVT.

• Authors: Tao Jiang, Yao Yao, Xingquan Xu, Kai Song, Pin Pan, Dongyang Chen, Zhihong Xu, Jin Dai, Jianghui Qin, Dongquan Shi, Qing Jiang
• Journal: Annals of vascular surgery (Ann Vasc Surg) Vol. 64 Pg. 175-180 (Apr 2020) ISSN: 1615-5947 [Electronic] Netherlands
• PMID: 31626936 (Publication Type: Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier Inc.

Chemical References

• Biomarkers
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Arthroplasty, Replacement, Knee
• Biomarkers (blood)
• China (epidemiology)
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Humans
• Incidence
• Male
• Middle Aged
• Osteoarthritis, Knee (diagnosis, epidemiology, surgery)
• Prevalence
• Retrospective Studies
• Risk Factors
• Venous Thrombosis (diagnostic imaging, epidemiology)