Animal studies have suggested that mushroom intake can alleviate
non-alcoholic fatty liver disease (
NAFLD) due to its anti-inflammatory and
antioxidant properties. However, the association between mushroom intake and
NAFLD is unknown in humans. We aimed to investigate the association of mushroom intake with
NAFLD among Chinese adults. This is a cross-sectional study of 24 236 adults (mean (standard deviation) age: 40·7 (sd 11·9) years; 11 394 men (47·0 %)). Mushroom intake was assessed via a validated FFQ. Newly diagnosed
NAFLD was identified based on the results of annual health examinations, including ultrasound findings and a self-reported history of the disease. Multiple logistic models were used to examine the association between mushroom intake and
NAFLD. The prevalence of newly diagnosed
NAFLD was 19·0 %. Compared with those consuming mushrooms less frequently (≤1 time/week), the fully adjusted OR of newly diagnosed
NAFLD were 0·95 (95 % CI 0·86, 1·05) for those consuming 2-3 times/week and 0·76 (95 % CI 0·63, 0·92) for those consuming ≥4 times/week (Pfor trend = 0·01). The inverse association was consistent in subgroups defined by age, sex and BMI. In conclusion, higher mushroom intake was significantly associated with lower prevalence of
NAFLD among Chinese adults. Future research is required to understand the causal association between mushroom intake and
NAFLD.