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Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy.

Abstract
A recent breakthrough in the discovery of thermally activated delayed fluorescence (TADF) emitters characterized by small single-triplet energy offsets (Ξ”EST) offers a wealth of new opportunities to exploit high-performance metal-free photosensitizers. In this report, two intrinsically cancer-mitochondria-targeted TADF emitters-based nanoparticles (TADF NPs) have been developed for two-photon-activated photodynamic therapy (PDT) and fluorescence imaging. The as-prepared TADF NPs integrate the merits of (1) high 1O2 quantum yield of 52%, (2) sufficient near-infrared light penetration depth due to two-photon activation, and (3) excellent structure-inherent mitochondria-targeting capabilities without extra chemical or physical modifications, inducing remarkable endogenous mitochondria-specific reactive oxygen species production and excellent cancer-cell-killing ability at an ultralow light irradiance. We believe that the development of such intrinsically multifunctional TADF NPs stemming from a single molecule will provide new insights into exploration of novel PDT agents with strong photosensitizing ability for various biomedical applications.
AuthorsJinfeng Zhang, Fang Fang, Bin Liu, Ji-Hua Tan, Wen-Cheng Chen, Zelin Zhu, Yi Yuan, Yingpeng Wan, Xiao Cui, Shengliang Li, Qing-Xiao Tong, Junfang Zhao, Xiang-Min Meng, Chun-Sing Lee
JournalACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 11 Issue 44 Pg. 41051-41061 (Nov 06 2019) ISSN: 1944-8252 [Electronic] United States
PMID31602976 (Publication Type: Journal Article)
Chemical References
  • Fluorescent Dyes
  • Photosensitizing Agents
  • Singlet Oxygen
Topics
  • Apoptosis (drug effects, radiation effects)
  • Cell Line, Tumor
  • Cell Survival (drug effects, radiation effects)
  • Fluorescent Dyes (chemistry)
  • Humans
  • Infrared Rays
  • Microscopy, Confocal
  • Microscopy, Fluorescence, Multiphoton
  • Mitochondria (drug effects, pathology)
  • Nanoparticles (chemistry, toxicity)
  • Neoplasms (drug therapy, metabolism, pathology)
  • Photochemotherapy
  • Photons
  • Photosensitizing Agents (chemistry, pharmacology)
  • Quantum Theory
  • Singlet Oxygen (metabolism)

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