Abstract |
A recent breakthrough in the discovery of thermally activated delayed fluorescence (TADF) emitters characterized by small single-triplet energy offsets (Ξ”EST) offers a wealth of new opportunities to exploit high-performance metal-free photosensitizers. In this report, two intrinsically cancer-mitochondria-targeted TADF emitters-based nanoparticles (TADF NPs) have been developed for two-photon-activated photodynamic therapy ( PDT) and fluorescence imaging. The as-prepared TADF NPs integrate the merits of (1) high 1O2 quantum yield of 52%, (2) sufficient near-infrared light penetration depth due to two-photon activation, and (3) excellent structure-inherent mitochondria-targeting capabilities without extra chemical or physical modifications, inducing remarkable endogenous mitochondria-specific reactive oxygen species production and excellent cancer-cell-killing ability at an ultralow light irradiance. We believe that the development of such intrinsically multifunctional TADF NPs stemming from a single molecule will provide new insights into exploration of novel PDT agents with strong photosensitizing ability for various biomedical applications.
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Authors | Jinfeng Zhang, Fang Fang, Bin Liu, Ji-Hua Tan, Wen-Cheng Chen, Zelin Zhu, Yi Yuan, Yingpeng Wan, Xiao Cui, Shengliang Li, Qing-Xiao Tong, Junfang Zhao, Xiang-Min Meng, Chun-Sing Lee |
Journal | ACS applied materials & interfaces
(ACS Appl Mater Interfaces)
Vol. 11
Issue 44
Pg. 41051-41061
(Nov 06 2019)
ISSN: 1944-8252 [Electronic] United States |
PMID | 31602976
(Publication Type: Journal Article)
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Chemical References |
- Fluorescent Dyes
- Photosensitizing Agents
- Singlet Oxygen
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Topics |
- Apoptosis
(drug effects, radiation effects)
- Cell Line, Tumor
- Cell Survival
(drug effects, radiation effects)
- Fluorescent Dyes
(chemistry)
- Humans
- Infrared Rays
- Microscopy, Confocal
- Microscopy, Fluorescence, Multiphoton
- Mitochondria
(drug effects, pathology)
- Nanoparticles
(chemistry, toxicity)
- Neoplasms
(drug therapy, metabolism, pathology)
- Photochemotherapy
- Photons
- Photosensitizing Agents
(chemistry, pharmacology)
- Quantum Theory
- Singlet Oxygen
(metabolism)
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