END-phenomenon negative bovine viral diarrhea virus that induces the host's innate immune response supports propagation of BVDVs with different immunological properties.

Abstract

Our previous study reported that persistently infected (PI) cattle of bovine viral diarrhea virus (BVDV) have co-infected with BVDV/END- and /END+ that promote and inhibit host's type-I interferon (IFN) production, respectively. However, the relationship between co-infection of immunologically distinct BVDVs and persistent infection as well as the biological significance of END- viruses remains unknown. Experiments using cultured cells revealed that END+ virus, which is unable to propagate in situations where the host's immune response is induced by IFN-α addition, is able to propagate under those conditions when co-infecting with END- virus. These results indicate that BVDV/END- can coexist with BVDV/END+ and that co-infection with END- viruses supports the propagation of END+ viruses. Our in vitro experiments strongly suggest that co-infection with END- virus is involved in the maintenance of persistent infection of BVDV.

• Authors: Mai Shiokawa, Tsutomu Omatsu, Yukie Katayama, Kaoru Nishine, Yuri Fujimoto, Shiori Uchiyama, Ken-Ichiro Kameyama, Makoto Nagai, Tetsuya Mizutani, Yoshihiro Sakoda, Akio Fukusho, Hiroshi Aoki
• Journal: Virology (Virology) Vol. 538 Pg. 97-110 (12 2019) ISSN: 1096-0341 [Electronic] United States
• PMID: 31590058 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Interferon-alpha

Topics

• Animals
• Bovine Virus Diarrhea-Mucosal Disease (genetics, immunology, virology)
• Cattle
• Classical Swine Fever (genetics, immunology, virology)
• Classical Swine Fever Virus (genetics, physiology)
• Diarrhea Viruses, Bovine Viral (genetics, immunology, physiology)
• Guinea Pigs
• Immunity, Innate
• Interferon-alpha (genetics, immunology)
• Swine