Impact of hypertension on cerebral microvascular structure in CPAP-treated obstructive sleep apnoea patients: a diffusion magnetic resonance imaging study.

Abstract

PURPOSE:

Obstructive sleep apnoea (OSA) is a highly prevalent sleep-related breathing disorder associated with hypertension, impaired peripheral vascular function and an increased risk of stroke. Evidence suggests that abnormalities of the cerebral microcirculation, such as capillary rarefication, may be present in these patients. We evaluated whether the presence of hypertension may affect the cerebral capillary architecture and function assessed by Intravoxel Incoherent Motion (IVIM) magnetic resonance imaging (MRI) in patients with continuous positive airway pressure (CPAP)-treated OSA.

METHODS:

Forty-one patients (88% male, mean age 57 ± 10 years) with moderate-to-severe OSA were selected and divided into two groups (normotensive vs. hypertensive). All hypertensive OSA patients were adherent with their antihypertensive medication. Cerebral microvascular structure was assessed in grey (GM) and white matter (WM) using an echo-planar diffusion imaging sequence with 14 different b values. A step-wise IVIM analysis algorithm was applied to compute true diffusion (D), perfusion fraction (f) and pseudo-diffusion (D*) values. Group comparisons were performed with the Wilcoxon-Mann-Whitney-Test. Regression analysis was adjusted for age.

RESULTS:

Diffusion- and perfusion-related indexes in middle-aged OSA normotensive patients were quantified in both tissue types (D [10-3 mm2/s]: GM = 0.83 ± 0.03; WM = 0.72 ± 0.03; f (%) GM = 0.09 ± 0.01; WM = 0.06 ± 0.01; D* [10-3 mm2/s]: GM = 7.72 ± 0.89; WM = 7.38 ± 0.98). In the examined tissue types, hypertension did not result in changes on the estimated MRI IVIM index values.

CONCLUSION:

Based on IVIM analysis, cerebral microvascular structure and function showed no difference between hypertensive and normotensive patients with moderate-to-severe OSA treated with CPAP. Treatment adherence with antihypertensive drug regime and, in turn, controlled hypertension seems not to affect microvascular structure and perfusion of the brain.

TRIAL REGISTRATION:

ClinicalTrials.gov Identifier: NCT02493673.

• Authors: Sira Thiel, Thomas Gaisl, Franziska Lettau, Andreas Boss, Sebastian Winklhofer, Malcolm Kohler, Cristina Rossi
• Journal: Neuroradiology (Neuroradiology) Vol. 61 Issue 12 Pg. 1437-1445 (Dec 2019) ISSN: 1432-1920 [Electronic] Germany
• PMID: 31529145 (Publication Type: Clinical Trial, Journal Article)

Topics

• Cerebrovascular Circulation
• Continuous Positive Airway Pressure
• Diffusion Magnetic Resonance Imaging
• Female
• Humans
• Hypertension (complications, drug therapy)
• Image Interpretation, Computer-Assisted
• Male
• Microvessels (diagnostic imaging)
• Middle Aged
• Sleep Apnea, Obstructive (complications, therapy)