Loss of NaV1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability.

Abstract

Mutations in voltage-dependent sodium channels cause severe autism/intellectual disability. In this issue of Neuron, Spratt et al. (2019) show that lowering expression of Nav1.2 channels attenuates backpropagation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent synaptic plasticity.

• Authors: Leonard K Kaczmarek
• Journal: Neuron (Neuron) Vol. 103 Issue 4 Pg. 551-553 (08 21 2019) ISSN: 1097-4199 [Electronic] United States
• PMID: 31437449 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• NAV1.2 Voltage-Gated Sodium Channel
• SCN2A protein, human

Topics

• Action Potentials
• Autistic Disorder
• Dendrites
• Humans
• Intellectual Disability
• NAV1.2 Voltage-Gated Sodium Channel
• Prefrontal Cortex