Current status of urinary diagnostic biomarkers for colorectal cancer.

Abstract

Fecal occult blood test (FOBT) and flexible sigmoidoscopy are the currently using screening methods for colorectal cancer (CRC). However, these methods still have problems of high false positive rates in FOBT and increased invasiveness and cost associated with endoscopy. The development of non-invasive biomarkers is thus important for the diagnosis of CRC. Urine is one of the most commonly used samples for mass screening owing to its non-invasive and simple process of collection; however, the discovery of urinary diagnostic biomarkers for malignancies is still challenging and developing. Since urine contains abundant substances reflecting systemic body condition, urinary biomarker might contribute to detect CRC in a completely non-invasive manner. In this review, we describe the current utility of urinary diagnostic biomarkers for CRC.

• Authors: Hiroyasu Iwasaki, Takaya Shimura, Hiromi Kataoka
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 498 Pg. 76-83 (Nov 2019) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 31421118 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers, Tumor

Topics

• Animals
• Biomarkers, Tumor (urine)
• Colorectal Neoplasms (diagnosis, urine)
• Diagnostic Errors
• Humans
• Mass Screening (methods)