Abstract | BACKGROUND: METHODS: RESULTS: The seroprevalence of complement-fixing antibodies was highest against the PvMSP3α central region (77.6%). IgG1, IgG3, and IgM were significantly correlated with C1q fixation, and both purified IgG and IgM were capable of mediating C1q fixation to PvMSP3α. Complement-fixing antibody levels were similar between age groups, but IgM was predominant in children and IgG3 more prevalent in adults. Levels of functional antibodies increased after acute infection through 7 days after treatment but rapidly waned by day 28. CONCLUSION: Our study demonstrates that PvMSP3α antibodies acquired during P. vivax infection can mediate complement fixation and shows the important influence of age in shaping these specific antibody responses. Further studies are warranted to understand the role of these functional antibodies in protective immunity against P. vivax malaria.
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Authors | Damian A Oyong, Danny W Wilson, Bridget E Barber, Timothy William, Jianlin Jiang, Mary R Galinski, Freya J I Fowkes, Matthew J Grigg, James G Beeson, Nicholas M Anstey, Michelle J Boyle |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 220
Issue 12
Pg. 1950-1961
(11 06 2019)
ISSN: 1537-6613 [Electronic] United States |
PMID | 31419296
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. |
Chemical References |
- Antibodies, Protozoan
- Antigens, Protozoan
- Immunoglobulin G
- Immunoglobulin M
- Protozoan Proteins
- merozoite surface protein 3, Plasmodium
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Protozoan
(blood, immunology)
- Antigens, Protozoan
(immunology)
- Female
- Humans
- Immunoglobulin G
(blood, immunology)
- Immunoglobulin M
(blood, immunology)
- Infant, Newborn
- Kinetics
- Malaria, Vivax
(drug therapy, immunology, parasitology)
- Male
- Merozoites
(immunology)
- Middle Aged
- Plasmodium vivax
(classification, genetics, immunology)
- Protozoan Proteins
(immunology)
- Seroepidemiologic Studies
- Young Adult
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