Abstract | BACKGROUND: OBJECTIVE: To evaluate the benefits of using sildenafil in pregnancy. SEARCHED STRATEGY: MEDLINE, ClinicalTrials.gov, Embase, LILACS and Cochrane databases were searched through September 2018. There was no restriction in language or year of publication. This study was registered in PROSPERO (CRD42017060288). SELECTION CRITERIA: Randomized clinical trials which used sildenafil for treatment or prevention of obstetric diseases compared with placebo were selected. DATA COLLECTION AND ANALYSIS: The results were obtained using the inverse variance method for continuous variables and Man-Whitney for categorical variables. MAIN RESULTS: Among a population of 598 pregnant women from the seven clinical trials included, 139 had pre-eclampsia, 275 had intrauterine growth restriction, and 184 had oligohydramnios. A significant increase of 222.58 grams [27.75 to 417.41] was observed in the fetal weight at birth of patients taking sildenafil. The other outcomes did not show any statistical significance. This may be due to the small number of patients used in each study and the great heterogeneity between the groups. CONCLUSIONS:
Sildenafil could be associated with increasing fetal weight at birth in placental insufficiency despite the limitations of this meta-analysis, even though more studies in this field are needed to introduce this drug into obstetric clinical practice.
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Authors | Raquel Domingues da Silva Ferreira, Romulo Negrini, Wanderley Marques Bernardo, Ricardo Simões, Sebastião Piato |
Journal | PloS one
(PLoS One)
Vol. 14
Issue 7
Pg. e0219732
( 2019)
ISSN: 1932-6203 [Electronic] United States |
PMID | 31339910
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
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Topics |
- Birth Weight
- Delivery, Obstetric
- Female
- Fetus
(drug effects)
- Gestational Age
- Headache
(chemically induced)
- Humans
- Infant
- Infant Mortality
- Labor, Obstetric
- Pregnancy
- Pregnancy Outcome
- Publication Bias
- Risk
- Sildenafil Citrate
(adverse effects, pharmacology)
- Umbilical Arteries
(physiology)
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