Abstract | BACKGROUND:
Vitamin D is involved in the physiological functions of several tissues, however, its deficiency may contribute to the development of various disorders. Recent research has been focusing on the role of vitamin D in the pathogenesis of endometriosis based on the evidence of the presence of vitamin D receptor and the enzymes required for vitamin D synthesis in the ectopic endometrium. Endometriosis, defined as the presence of endometrial glands and stroma in ectopic locations, is considered an estrogen-dependent disease and Vitamin D seems to have a role in modulation of the inflammatory state and proliferation of endometriotic cells. OBJECTIVE: This study aimed to review the available literature regarding the relationship between vitamin D and endometriosis as well as the effects of vitamin D supplementation. METHODS: A search on PubMed database has been performed. RESULTS: CONCLUSION: Although promising, the data analyzed are not sufficient to evidence a cause-effect relationship between VD status and endometriosis, therefore further studies are needed in order to better clarify the association between vitamin D and endometriosis, especially in the context of the possibility of new treatment options.
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Authors | Pierluigi Giampaolino, Luigi Della Corte, Virginia Foreste, Giuseppe Bifulco |
Journal | Current pharmaceutical design
(Curr Pharm Des)
Vol. 25
Issue 22
Pg. 2421-2427
( 2019)
ISSN: 1873-4286 [Electronic] United Arab Emirates |
PMID | 31333100
(Publication Type: Journal Article, Review)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
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Topics |
- Animals
- Endometriosis
(complications)
- Endometrium
(pathology)
- Female
- Humans
- Rats
- Vitamin D
(physiology)
- Vitamin D Deficiency
(complications)
- Vitamins
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