A local risk score model for venous thromboembolism prophylaxis for caesarean section in Chinese women and comparison with international guidelines.

Abstract

OBJECTIVE:

Recommendations for venous thromboembolism (VTE) prophylaxis from authoritative guidelines for women undergoing caesarean delivery differed significantly and may not be applicable to Chinese populations. We aim to formulate a local risk model for VTE prophylaxis for caesarean section women.

MATERIAL AND METHODS:

A local risk score model based on demographic, obstetric and medical parameters was used to assess the risk of VTE in women undergoing caesarean delivery from May 2017 to April 2018 in a regional obstetric unit. Women with increased risk (VTE Score ≥ 2) are given mechanical prophylaxis with pneumatic cuff and those with high risk (VTE Score ≥ 3) are additionally prescribed low molecular weight heparin (LMWH) as pharmacological prophylaxis in the early postpartum period. The risk scores obtained by applying other major guidelines were then compared.

RESULTS:

Of 859 patients were included for analysis, overweight (15.3%), advanced maternal age (9.7%), multiple pregnancy (5.1%), obesity (4.7%), and primary postpartum haemorrhage (4.1%) were the most common risk factors. Overall, 109 (12.7%) patients required mechanical prophylaxis and 28 (3.3%) patients required additional pharmacological prophylaxis. No patient had postpartum VTE events nor serious haemorrhage after receiving LMWH prophylaxis. In contrast, applying the Royal College of Obstetricians and Gynaecologists guidelines to our cohort, 649 (75.6%) patients would receive LMWH after caesarean section, compared with no patients under the American College of Obstetrics and Gynaecology guidelines.

CONCLUSIONS:

Our local risk score model avoided the need for large proportions of women to be subjected to pharmacological prophylaxis, and appeared safe and practical.

• Authors: W Y Lok, C W Kong, W W K To
• Journal: Taiwanese journal of obstetrics & gynecology (Taiwan J Obstet Gynecol) Vol. 58 Issue 4 Pg. 520-525 (Jul 2019) ISSN: 1875-6263 [Electronic] China (Republic : 1949- )
• PMID: 31307744 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Chemical References

• Anticoagulants
• Heparin, Low-Molecular-Weight

Topics

• Adult
• Anticoagulants (therapeutic use)
• Cesarean Section (adverse effects, methods)
• Cohort Studies
• Female
• Heparin, Low-Molecular-Weight (therapeutic use)
• Hong Kong
• Humans
• Internationality
• Maternal Age
• Needs Assessment
• Obesity (epidemiology)
• Odds Ratio
• Practice Guidelines as Topic
• Pregnancy
• Primary Prevention (methods)
• Prognosis
• Retrospective Studies
• Risk Assessment
• Venous Thromboembolism (etiology, prevention & control)