Viral conjunctivitis: a retrospective study in an Australian hospital.

Abstract

IMPORTANCE:

To update the literature on the current trends of viral conjunctivitis infections in Sydney, Australia.

BACKGROUND:

To find correlations between viral and patient characteristics on disease outcomes and to assess the rates of antibiotic and steroid use in patients with viral conjunctivitis prior to and after assessment by ophthalmology trainees.

DESIGN:

Retrospective single-centre case series.

PARTICIPANTS:

368 eyes of 224 patients diagnosed with viral conjunctivitis at the Sydney Eye Hospital from 1 st January - 31 st March 2017.

METHODS:

Patients were identified from hospital records or polymerase chain reaction results.

RESULTS:

368 eyes of 224 patients, median age 35.3 (range 7-82) and 59.8% males, were included. 152 (67.9%) patients presented already on antibiotic treatment. Most patients (83.5%) had no previous ocular history aside from 35 (15.6%) who were regular contact lens wearers. PCR was performed in 170 (75.9%) patients, with 92 (54.1%) positive for adenovirus, and 7 (4.1%) for HSV. The average duration of symptoms prior to presentation was 6.3 days. 177 (78.0%) patients presented within 1 week of symptom onset and these patients were more likely to be adenovirus positive on PCR (OR = 2.37). Patients with symptoms of longer duration were more likely to have photophobia (OR = 2.96) and have had steroid treatment (OR = 3.80).

CONCLUSIONS AND RELEVANCE:

Patients with viral conjunctivitis typically presented within a week of symptom onset, with bilateral disease and on topical antibiotics. Pseudomembranes and a palpable preauricular lymph node were not common. As treatments emerge for viral conjunctivitis patients may need to be encouraged to present earlier.

• Authors: Emmanuel Marinos, Maria Cabrera-Aguas, Stephanie Louise Watson
• Journal: Contact lens & anterior eye : the journal of the British Contact Lens Association (Cont Lens Anterior Eye) Vol. 42 Issue 6 Pg. 679-684 (12 2019) ISSN: 1476-5411 [Electronic] England
• PMID: 31300283 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 British Contact Lens Association. All rights reserved.

Chemical References

• Antiviral Agents

Topics

• Adenovirus Infections, Human (diagnosis, drug therapy, epidemiology)
• Adenoviruses, Human (isolation & purification)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antiviral Agents (therapeutic use)
• Australia (epidemiology)
• Child
• Conjunctivitis, Viral (diagnosis, drug therapy, epidemiology)
• Eye Infections, Viral (diagnosis, drug therapy, epidemiology)
• Female
• Herpes Simplex (diagnosis, drug therapy, epidemiology)
• Herpesvirus 1, Human (isolation & purification)
• Hospitals
• Humans
• Male
• Middle Aged
• Polymerase Chain Reaction
• Retrospective Studies