The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer.

Abstract

Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research.

• Authors: Qun Wang, Alexander Steger, Sven Mahner, Udo Jeschke, Helene Heidegger
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 13 (Jul 05 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 31284453 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor

Topics

• Biomarkers, Tumor (metabolism)
• Female
• Humans
• Macrophages (pathology)
• Models, Biological
• Uterine Cervical Neoplasms (pathology, therapy)