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Transoral robotic surgery in patients with stage III/IV hypopharyngeal squamous cell carcinoma: treatment outcome and prognostic factor.

Abstract
Background: We aimed to reduce the morbidity related to treatment and to preserve organ function in patients with hypopharyngeal squamous cell carcinoma (HPSCC) by applying a new surgical treatment protocol based on transoral robotic surgery (TORS). Aims/objectives: In this study, we analyzed the prognostic factors related to survival to confirm the validity and effectiveness of TORS in patients with advanced-stage HPSCC. Methods: We retrospectively analyzed the data of 44 HPSCC patients who had undergone TORS-based therapy. Results: In univariate analysis, only the surgical marginal status showed a statistically significant correlation with the survival of the patients (p = .009). In multivariate analysis, surgical margin status was the only statistically significant prognostic factor related to survival (p = .008). Forty-one patients (93.2%) recovered speech function sufficiently to perform daily conversation without artificial aids. Forty-one patients (93.2%) were able to ingest food orally. Conclusions: In the treatment of advanced hypopharyngeal cancer, TORS-based therapy helped the surgeon obtain a clear surgical margin in patients with HPSCC, and it showed superior oncologic and functional outcomes compared to the existing treatment methods.
AuthorsYoung Min Park, Da Hee Kim, Min Seok Kang, Jae Yol Lim, Yoon Woo Koh, Se-Heon Kim
JournalActa oto-laryngologica (Acta Otolaryngol) Vol. 139 Issue 9 Pg. 816-822 (Sep 2019) ISSN: 1651-2251 [Electronic] England
PMID31268399 (Publication Type: Journal Article)
Topics
  • Adult
  • Aged
  • Analysis of Variance
  • Cohort Studies
  • Disease-Free Survival
  • Female
  • Humans
  • Hypopharyngeal Neoplasms (drug therapy, mortality, pathology, surgery)
  • Male
  • Margins of Excision
  • Middle Aged
  • Minimally Invasive Surgical Procedures (methods, mortality)
  • Mouth
  • Natural Orifice Endoscopic Surgery (methods)
  • Neoadjuvant Therapy
  • Neoplasm Invasiveness (pathology)
  • Neoplasm Staging
  • Predictive Value of Tests
  • Prognosis
  • Retrospective Studies
  • Risk Assessment
  • Robotic Surgical Procedures (methods)
  • Squamous Cell Carcinoma of Head and Neck (drug therapy, mortality, pathology, surgery)
  • Survival Analysis

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