Abstract | BACKGROUND: OBJECTIVE: The current study aimed to investigate the relation between DII and DIL and risk of glioma in a case-control study among Iranian adults. METHODS: In this hospital-based case-control study, 128 pathologically confirmed cases of glioma and 256 age and sex-matched controls were enrolled. Dietary intakes of study participants were assessed using a validated Block-format 123-item semi-quantitative FFQ. DII and DIL were computed using a published food insulin index (FII) data. RESULTS: A significant positive association was found between DIL and glioma (OR: 3.56; 95% CI: 1.85-6.58, P < 0.001); such that after controlling for potential confounders, participants in the highest quartile of DIL had 2.95 times greater odds of glioma than those in the lowest quartile (OR: 2.95; 95% CI: 1.40-6.24, Ptrend = 0.006). Furthermore, we observed a significant positive association between DII and glioma (OR: 2.65; 95% CI: 1.43-4.93, Ptrend = 0.001). This association remained significant even after considering energy intake (OR: 2.66; 95% CI: 1.43-4.95, Ptrend = 0.001). However, when further potential confounders were taken into account, this relationship became non-significant (OR: 1.87; 95% CI: 0.92-3.80, Ptrend = 0.03), despite a significant trend of increased odds ratios (P = 0.03). CONCLUSIONS: In conclusion, we found a significant positive association between DIL and odds of glioma. DII was not significantly associated with odds of glioma after controlling for confounders.
|
Authors | Javad Anjom-Shoae, Mehdi Shayanfar, Minoo Mohammad-Shirazi, Omid Sadeghi, Giuve Sharifi, Fereydoun Siassi, Ahmad Esmaillzadeh |
Journal | Nutritional neuroscience
(Nutr Neurosci)
Vol. 24
Issue 5
Pg. 354-362
(May 2021)
ISSN: 1476-8305 [Electronic] England |
PMID | 31240996
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Brain Neoplasms
(epidemiology)
- Case-Control Studies
- Diet
- Female
- Glioma
(epidemiology)
- Humans
- Insulin
(analysis)
- Iran
- Male
- Middle Aged
- Odds Ratio
|