Abstract | BACKGROUND: METHODS: A total of 107 patients with stage IB to IIB CC, who underwent radical hysterectomy at Tottori University Hospital between 2006 and 2015, were included in this study. Serum samples were collected prior to radical hysterectomy, and levels of VEGF-A, VEGF-C, VEGFR-1, and VEGFR-2 were analyzed by enzyme-linked immunosorbent assays. We evaluated the association between the levels of these angiogenic factors and clinicopathologic variables. Survival analysis of 93 patients treated between 2006 and 2013 was performed. RESULTS: The levels of VEGF-A in patients with bulky tumor, pelvic lymph-node involvement (PLNI), and parametrial infiltration (PI) were significantly higher than those in patients without these factors (P = 0.022, P = 0.020, and P = 0.0013, respectively). The overall survival (OS) of patients with high VEGF-A and VEGFR-2 defined by median levels was significantly lower than the OS of patients with low levels of VEGF-A and VEGFR-2 (P = 0.014, P = 0.012, respectively). Multivariate analysis revealed that PLNI, serum VEGF-A levels, and serum VEGFR-2 levels were independent prognostic factors for OS (hazard ratio for VEGF-A 3.42, 95% CI 1.07-13.2; hazard ratio for VEGFR-2 6.37, 95% CI 1.59-43.5). CONCLUSION:
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Authors | Mayumi Sawada, Tetsuro Oishi, Hiroaki Komatsu, Shinya Sato, Jun Chikumi, Michiko Nonaka, Akiko Kudoh, Daiken Osaku, Tasuku Harada |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 24
Issue 12
Pg. 1612-1619
(Dec 2019)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 31236742
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor C
- KDR protein, human
- Vascular Endothelial Growth Factor Receptor-1
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Female
- Humans
- Lymph Nodes
(pathology)
- Middle Aged
- Prognosis
- Survival Analysis
- Uterine Cervical Neoplasms
(blood, mortality, surgery)
- Vascular Endothelial Growth Factor A
(blood)
- Vascular Endothelial Growth Factor C
(blood)
- Vascular Endothelial Growth Factor Receptor-1
(blood)
- Vascular Endothelial Growth Factor Receptor-2
(blood)
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