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Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.

Abstract
The level of nicotinamide adenine dinucleotide (NAD) decreases in Parkinson's disease (PD), and its reduction has been reported to be involved in many age-associated neurodegenerative pathologies. Thus, we investigated whether NAD replenishment is beneficial in a 6-hydroxydopamine (6-OHDA)-induced mouse model of PD. Preinjection with NAD in the striatum ameliorated motor deficits and dopaminergic neuronal damage in the substantia nigra and striatum of a mouse model of PD. Moreover, preincubation with NAD protected PC12 cells against the loss of cell viability, morphological damage, oxidative stress and mitochondrial dysfunction caused by 6-OHDA. These results add credence to the beneficial role of NAD against parkinsonian neurodegeneration in mouse models of PD, provide evidence for the potential of NAD for the prevention of PD, and suggest that NAD prevents pathological changes in PD via decreasing mitochondrial dysfunctions.
AuthorsChang Shan, Yan-Ling Gong, Qian-Qian Zhuang, Yan-Fang Hou, Shu-Min Wang, Qin Zhu, Guo-Rui Huang, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Sheng-Tian Li, Jian-Min Liu
JournalProgress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 94 Pg. 109670 (08 30 2019) ISSN: 1878-4216 [Electronic] England
PMID31220519 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
Chemical References
  • Neuroprotective Agents
  • NAD
  • Oxidopamine
Topics
  • Animals
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Corpus Striatum (drug effects)
  • Disease Models, Animal
  • Dopaminergic Neurons (drug effects, pathology)
  • Humans
  • Male
  • Mice
  • Microinjections
  • Mitochondria (drug effects)
  • Motor Activity (drug effects)
  • NAD (administration & dosage, pharmacology)
  • Nerve Degeneration (prevention & control)
  • Neuroprotective Agents (administration & dosage, pharmacology)
  • Oxidative Stress (drug effects)
  • Oxidopamine
  • Parkinson Disease, Secondary (chemically induced, pathology, prevention & control)

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