Abstract | BACKGROUND/PURPOSE: Our previous studies found relatively higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia in patients with different types of oral mucosal diseases. This study evaluated whether patients with oral precancerous lesions (oral precancer patients) had significantly higher frequencies of anemia, hematinic deficiencies, and hyperhomocysteinemia than healthy control subjects. METHODS: RESULTS: We found significantly lower mean serum iron (for women only), vitamin B12, and folic acid levels and a significantly higher mean serum homocysteine level in oral precancer patients than in healthy control subjects (all P-values < 0.05). Moreover, 131 oral precancer patients had significantly higher frequencies of blood hemoglobin (3.1%), vitamin B12 (43.5%), and folic acid (46.6%) deficiencies and hyperhomocysteinemia (22.1%) than 131 healthy control subjects (all P-values < 0.05). Of 131 oral precancer patients, lower mean serum folic acid levels were found in 87 cigarette smokers than in 44 non-smokers (P = 0.002), in 26 smokers consuming > 20 cigarettes per day than in 61 smokers consuming ≤ 20 cigarettes per day (P = 0.024), and in 52 betel quid chewers than in 79 non-chewers (P = 0.051). CONCLUSION:
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Authors | Yu-Hsueh Wu, Yang-Che Wu, Fang-Yeh Chu, Shih-Jung Cheng, Andy Sun, Hsin-Ming Chen |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 118
Issue 9
Pg. 1299-1307
(Sep 2019)
ISSN: 0929-6646 [Print] Singapore |
PMID | 31202497
(Publication Type: Journal Article)
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Copyright | Copyright © 2019. Published by Elsevier B.V. |
Chemical References |
- Autoantibodies
- Hematinics
- Hemoglobins
- Folic Acid
- Iron
- Vitamin B 12
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Topics |
- Adult
- Aged
- Anemia
(etiology)
- Autoantibodies
(blood)
- Case-Control Studies
- Erythrocyte Indices
- Female
- Folic Acid
(blood)
- Folic Acid Deficiency
(blood)
- Hematinics
- Hemoglobins
(analysis)
- Humans
- Hyperhomocysteinemia
(blood)
- Iron
(blood)
- Leukoplakia, Oral
(blood)
- Male
- Middle Aged
- Mouth Diseases
(blood, pathology)
- Parietal Cells, Gastric
(immunology)
- Sex Factors
- Taiwan
- Vitamin B 12
(blood)
- Vitamin B 12 Deficiency
(blood)
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