[PD-L1-Mediated Immune Escape Mechanism of Cancer Stem-Like Cells].

Abstract

Immune checkpoint inhibitors(ICIs)have provided great success in cancer treatment field, and immunotherapies using ICIs have become standard therapy for several cancers. Cancer stem-like cells(CSCs)are defined by their higher tumorigenicity and resistance to chemotherapy and radiotherapy, thus they are supposed to be responsible for recurrence and distant metastasis. Therefore, control of CSCs is a key factor to improve patients' prognosis. In this review article, we summarize the expression of PD-L1, a molecular target of ICIs, in CSCs, and discuss the possibility of CSC-targeting immunotherapy using ICIs.

• Authors: Masahiro Matsuki, Yoshihiko Hirohashi, Toshihiko Torigoe
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 5 Pg. 850-854 (May 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 31189802 (Publication Type: Journal Article, Review)

Chemical References

• B7-H1 Antigen

Topics

• B7-H1 Antigen
• Humans
• Immunotherapy
• Neoplasms
• Neoplastic Stem Cells
• Prognosis