Abstract | BACKGROUND AND OBJECTIVES: Patients undergoing lung resection surgery are at risk of developing postoperative acute kidney injury. Determination of cytokine levels allows the detection of an early inflammatory response. We investigated any temporal relationship among perioperative inflammatory status and development of acute kidney injury after lung resection surgery. Furthermore, we evaluated the impact of acute kidney injury on outcome and analyzed the feasibility of cytokines to predict acute kidney injury. METHODS: We prospectively analyzed 174 patients scheduled for elective lung resection surgery with intra-operative periods of one-lung ventilation. Fiberoptic broncho-alveolar lavage was performed in each lung before and after one-lung ventilation periods for cytokine analysis. As well, cytokine levels were measured from arterial blood samples at five time points. Acute kidney injury was diagnosed within 48h of surgery based estabilished criteria for its diagnosis. We analyzed the association between acute kidney injury and cardiopulmonary complications, length of intensive care unit and hospital stays, intensive care unit re-admission, and short-term and long-term mortality. RESULTS: CONCLUSIONS:
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Authors | Cristina Monteserín Matesanz, Francisco de la Gala, Lisa Rancan, Patricia Piñeiro, Carlos Simón, Alberto Tejedor, Elena Vara, Jorge L Gonzalez-Cantero, Ignacio Garutti |
Journal | Brazilian journal of anesthesiology (Elsevier)
(Braz J Anesthesiol)
2019 May - Jun
Vol. 69
Issue 3
Pg. 242-252
ISSN: 2352-2291 [Electronic] Brazil |
Vernacular Title | Valor preditivo das citocinas plasmáticas para lesão renal aguda após cirurgia de ressecção pulmonar: estudo observacional prospectivo. |
PMID | 31133282
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2019. Publicado por Elsevier Editora Ltda. |
Chemical References |
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Topics |
- Acute Kidney Injury
(diagnosis, epidemiology, etiology)
- Aged
- Bronchoalveolar Lavage
- Cytokines
(blood)
- Female
- Humans
- Incidence
- Male
- Middle Aged
- One-Lung Ventilation
- Postoperative Complications
(diagnosis, epidemiology)
- Predictive Value of Tests
- Prospective Studies
- Pulmonary Surgical Procedures
(adverse effects, methods)
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