Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry.

Abstract

AIMS/INTRODUCTION:

Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD).

MATERIALS AND METHODS:

In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis.

RESULTS:

A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54-4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39-2.70) and ESRD (OR 2.36, 95% CI 1.32-4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58-4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture.

CONCLUSIONS:

Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.

• Authors: Yuji Komorita, Masanori Iwase, Yasuhiro Idewaki, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Masahito Yoshinari, Ai Murao-Kimura, Yutaro Oku, Udai Nakamura, Takanari Kitazono
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 11 Issue 1 Pg. 62-69 (Jan 2020) ISSN: 2040-1124 [Electronic] Japan
• PMID: 31111663 (Publication Type: Journal Article)
• Copyright: © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Topics

• Aged
• Cardiovascular Diseases (complications, mortality)
• Cause of Death (trends)
• Cohort Studies
• Diabetes Mellitus, Type 2 (complications, mortality)
• Female
• Follow-Up Studies
• Hip Fractures (etiology, mortality)
• Humans
• Japan
• Kidney Failure, Chronic (complications, mortality)
• Male
• Middle Aged
• Prognosis
• Registries (statistics & numerical data)
• Risk Factors
• Survival Rate