Co-Effect of Serum Galectin-3 and High-Density Lipoprotein Cholesterol on the Prognosis of Acute Ischemic Stroke.

Abstract

GOAL:

The association of combined galectin-3 and high-density lipoprotein cholesterol (HDL-C) with prognosis of acute ischemic stroke remains unknown. This study aimed to evaluate the coeffect of galectin-3 and HDL-C on death and vascular events within 1 year after ischemic stroke.

MATERIALS AND METHODS:

Based on China Antihypertensive Trial in Acute Ischemic Stroke, a prospective study was conducted among 2970 patients with acute ischemic stroke. The primary outcome was a combination of death and vascular events within 1 year after ischemic stroke. The secondary outcomes were separately those of recurrent stroke, vascular events, and death.

FINDINGS:

The multivariate adjusted hazard ratios (95% confidence intervals) of primary outcome, recurrent stroke, and vascular events were 1.54 (1.07-2.20), 1.78 (1.08-2.95), and 1.92 (1.26-2.94), respectively, in patients with both high galectin-3 and low HDL-C compared to those with both low galectin-3 and high HDL-C. The addition of galectin-3 and HDL-C to conventional factors significantly improved predictive value. Net reclassification index was 15.7% for primary outcome, 18.3% for recurrent stroke, and 20.5% for vascular events.

CONCLUSION:

Combination of high galectin-3 and low HDL-C was associated with primary outcome, recurrent stroke, and vascular events within 1 year after ischemic stroke, suggesting that the combination of galectin-3 and HDL-C may be used to identify the individuals at risk of poor prognosis after ischemic stroke.

• Authors: Nimei Zeng, Aili Wang, Tan Xu, Chongke Zhong, Xiaowei Zheng, Zhengbao Zhu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 28 Issue 7 Pg. 1879-1885 (Jul 2019) ISSN: 1532-8511 [Electronic] United States
• PMID: 31085131 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Blood Proteins
• Cholesterol, HDL
• Galectin 3
• Galectins
• LGALS3 protein, human

Topics

• Adult
• Aged
• Biomarkers (blood)
• Blood Proteins
• Brain Ischemia (blood, diagnosis, mortality, therapy)
• China
• Cholesterol, HDL (blood)
• Female
• Galectin 3 (blood)
• Galectins
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Recurrence
• Risk Assessment
• Risk Factors
• Single-Blind Method
• Stroke (blood, diagnosis)
• Time Factors
• Young Adult