Interaction of sigma-1 receptor modulators with seizure development in pentylenetetrazole-induced kindled mice.

Abstract

This study aimed to investigate the effects of sigma receptor modulators, opipramol and BD-1063, on epileptogenesis in pentylenetetrazole (PTZ)-kindling model of epilepsy. Mice (n = 6/group) were received PTZ (30 mg/kg), PTZ plus opipramol (5 or 10 mg/kg), PTZ plus opipramol (5 mg/kg) plus BD-1063 (5 mg/kg, a selective sigma-1 receptor antagonist), and PTZ plus BD-1063 on alternate days for 15 days. Opipramol (5 and 10 mg/kg) + PTZ groups became fully kindled and had higher seizure scores compared to the PTZ group. In contrast, the PTZ plus BD-1063 and the PTZ plus opipramol (5 mg/kg) plus BD-1063 group did not show full kindling. These findings indicate that opipramol has a pro-convulsant effect, which is possibly mediated through activation of sigma-1 receptors.

• Authors: Masoumeh Emamghoreishi, Marzieh Shahpari, Mojtaba Keshavarz
• Journal: Epilepsy research (Epilepsy Res) Vol. 154 Pg. 74-76 (08 2019) ISSN: 1872-6844 [Electronic] Netherlands
• PMID: 31078073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• 1-(2-(3,4-dichlorophenyl)ethyl)-4-methylpiperazine
• Adrenergic Uptake Inhibitors
• Convulsants
• Piperazines
• Receptors, sigma
• sigma-1 receptor
• Opipramol
• Pentylenetetrazole

Topics

• Adrenergic Uptake Inhibitors (toxicity)
• Animals
• Convulsants (toxicity)
• Kindling, Neurologic (drug effects, physiology)
• Male
• Mice
• Mice, Inbred BALB C
• Opipramol (toxicity)
• Pentylenetetrazole (toxicity)
• Piperazines (pharmacology, therapeutic use)
• Random Allocation
• Receptors, sigma (agonists, antagonists & inhibitors, physiology)
• Seizures (chemically induced, physiopathology, prevention & control)