Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons With Human Immunodeficiency Virus.

Abstract

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque (P = .01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = -0.19; P = .02) and noncalcified coronary plaque (ρ = -0.24; P = .004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration. NCT00455793.

• Authors: Lindsay T Fourman, Charles F Saylor, Lediya Cheru, Kathleen Fitch, Sara Looby, Kiana Keller, Jake A Robinson, Udo Hoffmann, Michael T Lu, Tricia Burdo, Janet Lo
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 221 Issue 4 Pg. 510-515 (02 03 2020) ISSN: 1537-6613 [Electronic] United States
• PMID: 31077265 (Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Chemical References

• Anti-HIV Agents
• Biomarkers
• IL10 protein, human
• RNA, Viral
• Interleukin-10

Topics

• Adult
• Anti-HIV Agents (therapeutic use)
• Biomarkers (blood)
• Computed Tomography Angiography
• Coronary Artery Disease (blood, complications, diagnostic imaging)
• Female
• HIV Infections (complications, drug therapy, virology)
• HIV-1 (genetics)
• Humans
• Inflammation (blood, immunology)
• Interleukin-10 (blood, immunology)
• Male
• Middle Aged
• Plaque, Atherosclerotic (diagnostic imaging)
• RNA, Viral (genetics)
• Risk Factors