Lymphocytes upregulate CD36 in adipose tissue and liver.

Abstract

CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5-40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.

• Authors: Jacob Couturier, Alli M Nuotio-Antar, Neeti Agarwal, Gregory K Wilkerson, Pradip Saha, Viraj Kulkarni, Samir K Lakhashe, Juan Esquivel, Pramod N Nehete, Ruth M Ruprecht, K Jagannadha Sastry, Jennifer M Meyer, Lori R Hill, Jordan E Lake, Ashok Balasubramanyam, Dorothy E Lewis
• Journal: Adipocyte (Adipocyte) Vol. 8 Issue 1 Pg. 154-163 (12 2019) ISSN: 2162-397X [Electronic] United States
• PMID: 31035848 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• CD36 Antigens

Topics

• Adipose Tissue (cytology, metabolism)
• Animals
• CD36 Antigens (genetics, metabolism)
• CD4-Positive T-Lymphocytes (metabolism)
• CD8-Positive T-Lymphocytes (metabolism)
• Humans
• Liver (cytology, metabolism)
• Macaca mulatta
• Male
• Mice
• Mice, Inbred C57BL
• Up-Regulation