How Each Component of Betel Quid Is Involved in Oral Carcinogenesis: Mutual Interactions and Synergistic Effects with Other Carcinogens-a Review Article.

Abstract

PURPOSE OF REVIEW:

The roles of the components of betel quid in oral carcinogenesis remain unclear. The purpose of the present review is to highlight the effect of each component of betel quid and to discuss the synergistic effects of other carcinogens along with betel quid in the development of oral cancer in habitual betel quid chewers.

RECENT FINDINGS:

Betel quid may synergistically participate in carcinogenesis by disrupting the compositions of oral microbiota, accompanied by endotoxins secretion and reactive oxygen species (ROS) production. Microbiome dysbiosis mediated by synergistic effects of betel quid chewing, smoking, and alcohol drinking is possibly linked to oral carcinogenesis, which is firstly discussed in this report. Betel quid and other carcinogenic components, mainly contribute to downregulate the antioxidant proteins and lead to the induction of ROS. The elimination of ROS may prove most effective chemoprevention for betel quid-mediated oral carcinogenesis.

• Authors: Shajedul Islam, Malsantha Muthumala, Hirofumi Matsuoka, Osamu Uehara, Yasuhiro Kuramitsu, Itsuo Chiba, Yoshihiro Abiko
• Journal: Current oncology reports (Curr Oncol Rep) Vol. 21 Issue 6 Pg. 53 (04 26 2019) ISSN: 1534-6269 [Electronic] United States
• PMID: 31028548 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Carcinogens
• Reactive Oxygen Species

Topics

• Antioxidants (therapeutic use)
• Areca (chemistry, toxicity)
• Carcinogenesis
• Carcinogens (chemistry, toxicity)
• Dysbiosis
• Humans
• Inflammation
• Mouth Mucosa (microbiology, pathology)
• Mouth Neoplasms (etiology, microbiology, prevention & control)
• Reactive Oxygen Species (toxicity)