Abstract | OBJECTIVES: METHODS: Fifty-two patients who met the classification criteria of SAPHO syndrome were included in this study. Clinical data and disease activity markers were collected including erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein ( hsCRP), pain visual analogue scale (VAS), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Serum immunoglobin ( IgA, IgM, and IgG) and IgG subclass ( IgG1, IgG2, IgG3, and IgG4) levels were determined using the immunonephelometric assay. RESULTS: Raised serum IgG4 levels (>1400 mg/dL) were detected in 23% (12/52) of patients. Patients with elevated sIgG4 levels had significantly higher pain VAS (5.42±2.76 vs. 3.08±1.78, p=0.02), BASMI (1.80±1.64 vs. 0.38±0.94, p=0.03) and ASDAS (3.20±0.65 vs. 1.74±0.58, p<0.001) levels compared with patients with normal sIgG4 levels. This difference was also observed for ESR (38.2 vs. 22.2 mm/h, p=0.01) and serum CRP (21.0 vs. 2.2 mg/L, p=0.04) levels, which also positively correlated with sIgG4 levels. We also included 4 patients whose IgG4 levels decreased and correlated with the decrease in hsCRP and ESR levels after treatment. CONCLUSIONS: Elevated sIgG4 levels are common in patients with SAPHO syndrome and are associated with high disease activity. Further investigations are needed for this phenomenon.
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Authors | Chen Li, Yirong Xiang, Xia Wu, Yihan Cao, Yanxue Zhao, Xiaochuan Sun, Nan Wu, Wen Zhang |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
2020 Jan-Feb
Vol. 38
Issue 1
Pg. 35-41
ISSN: 0392-856X [Print] Italy |
PMID | 31025928
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Immunoglobulin G
- C-Reactive Protein
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Topics |
- Acquired Hyperostosis Syndrome
(blood, diagnosis, immunology)
- Biomarkers
(blood)
- Blood Sedimentation
- C-Reactive Protein
- Humans
- Immunoglobulin G
(blood)
- Severity of Illness Index
- Spondylitis, Ankylosing
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