Indocyanine Green Fluorescence Imaging of the Tracheal Blood Flow During Esophagectomy.

Abstract

BACKGROUND:

Tracheobronchial ischemia and necrosis are uncommon causes of pulmonary complications that can be lethal on development. Surgical manipulation considering tracheal blood flow is important in radical esophagectomy with extensive lymph node dissection. This study introduces a novel method for assessing tracheal blood perfusion using indocyanine green (ICG) fluorescence imaging.

MATERIALS AND METHODS:

Twenty patients who underwent esophagectomy with lymph node dissection for esophageal cancer were prospectively enrolled in this study. Tracheal blood flow after esophagectomy was quantitatively assessed using ICG fluorescence imaging. Region-of-interest software was used, and a time-intensity curve was created for the quantitative assessment of tracheal blood flow.

RESULTS:

We assessed ICG fluorescence imaging of the trachea during esophagectomy for esophageal cancer in all 20 cases. In the quantitative assessment of this pilot study, postoperative tracheal ischemic change and sputum discharge disorder tended to be associated with decreased tracheal blood flow (P = 0.084, P = 0.044). Resection of the right bronchial artery (BA) tended to be associated with decreased tracheal blood flow (P = 0.109), but the preoperative treatment, including chemotherapy and chemoradiotherapy, did not influence tracheal blood flow (P = 0.861, P = 0.435). The subgroup analysis of the preoperative chemoradiation group showed that the tracheal blood flow was significantly reduced with right BA resection compared with right BA preservation (P = 0.049).

CONCLUSIONS:

We assessed ICG fluorescence imaging of the trachea during esophagectomy for esophageal cancer. Further studies are needed to explore the significance of the assessment of tracheal blood flow during esophagectomy using ICG fluorescence imaging.

• Authors: Keijiro Sugimura, Hiroshi Miyata, Naoki Shinno, Yoshitomo Yanagimoto, Kazuyoshi Yamamoto, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Masahiko Yano
• Journal: The Journal of surgical research (J Surg Res) Vol. 241 Pg. 1-7 (09 2019) ISSN: 1095-8673 [Electronic] United States
• PMID: 31004867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Fluorescent Dyes
• Indocyanine Green

Topics

• Aged
• Bronchial Arteries (diagnostic imaging, surgery)
• Esophageal Neoplasms (surgery)
• Esophagectomy (adverse effects, methods)
• Female
• Fluorescent Dyes (administration & dosage)
• Humans
• Indocyanine Green (administration & dosage)
• Ischemia (etiology, prevention & control)
• Lymph Node Excision (adverse effects, methods)
• Male
• Middle Aged
• Optical Imaging
• Pneumonia (epidemiology, etiology, prevention & control)
• Postoperative Complications (epidemiology, etiology, prevention & control)
• Prospective Studies
• Regional Blood Flow
• Surgery, Computer-Assisted (adverse effects, methods)
• Trachea (blood supply, diagnostic imaging)