Abstract |
Sonodynamic therapy (SDT) triggered by ultrasound (US) has attracted increasing attention owing to its abilities to overcome critical limitations including low tissue-penetration depth and phototoxicity in photodynamic therapy. Herein, the design of a new type of sonosensitizer is revealed, namely, ultrasmall oxygen-deficient bimetallic oxide MnWOX nanoparticles, for multimodal imaging-guided enhanced SDT against cancer. As-made MnWOX nanoparticles with poly( ethylene glycol) (PEG) modification show high physiological stability and biocompatibility. Interestingly, such MnWOX -PEG nanoparticles exhibit highly efficient US-triggered production of 1 O2 and •OH, higher than that of previously reported sonosensitizers (e.g., protoporphyrin IX and titanium dioxide), because the oxygen-deficient structure of MnWOX serves as an electron trap site to prevent electron-hole recombination. The glutathione depletion capability of MnWOX -PEG can also further favor SDT-triggered cancer cell killing. With efficient tumor homing as illustrated by computer tomography and magnetic resonance imaging, MnWOX -PEG enables effective destruction of mouse tumors under US stimulation. After accomplishing its therapeutic functions, MnWOX -PEG can be metabolized by the mouse body without any long-term toxicity. Herein, a new type of sono-sensitizing agent with high SDT efficacy, multimodal imaging functions, and rapid clearance is presented, an agent which is promising for noninvasive SDT cancer treatment.
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Authors | Fei Gong, Liang Cheng, Nailin Yang, Oshra Betzer, Liangzhu Feng, Qiang Zhou, Yonggang Li, Ruihua Chen, Rachela Popovtzer, Zhuang Liu |
Journal | Advanced materials (Deerfield Beach, Fla.)
(Adv Mater)
Vol. 31
Issue 23
Pg. e1900730
(Jun 2019)
ISSN: 1521-4095 [Electronic] Germany |
PMID | 30977247
(Publication Type: Journal Article)
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Copyright | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine
- Carbocyanines
- Coloring Agents
- Manganese Compounds
- Oxides
- Polyethylene Glycols
- manganese oxide
- tungsten oxide
- Glutathione
- Oxygen
- Tungsten
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Topics |
- Animals
- Apoptosis
- Carbocyanines
(chemistry)
- Cell Line, Tumor
- Cell Survival
- Coloring Agents
(chemistry)
- Glutathione
(metabolism)
- Humans
- Manganese Compounds
(chemistry)
- Metal Nanoparticles
(chemistry, therapeutic use)
- Mice
- Neoplasm Transplantation
- Oxides
(chemistry)
- Oxygen
(chemistry)
- Polyethylene Glycols
(chemistry)
- Tungsten
(chemistry)
- Ultrasonic Therapy
(methods)
- Ultrasonography
(methods)
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