Fluorescein angiography of the corneal limbus--drug effects on capillary blood flow.

Abstract

By means of fluorescein angiography, plasma flow through the capillaries at the limbus corneae is demonstrated. The number of stained capillaries at a given time served as a measure of capillary perfusion. Even without drug the entire capillary system is perfused at least by plasma. Tolazoline enhanced the velocity of perfusion (P = 2alpha less than 0.01), epinephrine caused a marked capillary constriction (P = 2alpha less than 0.01), as well as--to a lesser extent--did dexamethasone (P = 2alpha less than 0.05). Dionine caused hyperemia, but the data varied much more than after tolazoline. In addition, dionine enhanced the dye leakage from the vessels.

• Authors: D Friedburg, B Meissner
• Journal: Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology (Albrecht Von Graefes Arch Klin Exp Ophthalmol) Vol. 207 Issue 3 Pg. 213-9 (Aug 16 1978) ISSN: 0065-6100 [Print] Germany
• PMID: 309738 (Publication Type: Journal Article)

Chemical References

• Dexamethasone
• Tolazoline
• Ethylmorphine
• Epinephrine

Topics

• Adult
• Capillaries (drug effects)
• Cornea (blood supply)
• Dexamethasone (pharmacology)
• Epinephrine (pharmacology)
• Ethylmorphine (pharmacology)
• Female
• Fluorescein Angiography
• Humans
• Male
• Middle Aged
• Regional Blood Flow (drug effects)
• Tolazoline (pharmacology)