Carbon dioxide removal using low bicarbonate dialysis in rodents.

Abstract

BACKGROUND:

Extracorporeal carbon dioxide removal may be used to manage hypercapnia, but compared to dialysis, it's not widely available. A recent in vitro study showed that dialysis with low bicarbonate dialysates removes CO2.

OBJECTIVE:

To show that bicarbonate dialysis removes CO2 in an animal model to validate in-vitro findings and quantify the effect on arterial pH.

METHODS:

Male Sprague-Dawley hypercapnic rats were dialyzed with either a conventional dialysate (PrismasolTM) or a bicarbonate-free dialysate (Bicarb0). The effect of dialysis on standard blood gases and electrolytes was measured.

RESULTS:

Partial pressure of CO2 and bicarbonate concentration in blood decreased significantly after exposure to Bicarb0 compared to PrismasolTM (filter outflow values 12.8 vs 81.1 mmHg; p < 0.01 for CO2 and 3.5 vs 22.0 mmol/L; p < 0.01 for bicarbonate). Total CO2 content of blood was reduced by 459 mL/L during dialysis with Bicarb0 (filter inflow 546 ± 91 vs filter outflow 87 ± 52 mL/L; p < 0.01), but was not significantly reduced with PrismasolTM.

CONCLUSIONS:

Bicarbonate dialysis removes CO2 at rates comparable to existing low-flow ECCO2R.

• Authors: Lien H Vu, John A Kellum, William J Federspiel, Matthew E Cove
• Journal: Perfusion (Perfusion) Vol. 34 Issue 7 Pg. 578-583 (10 2019) ISSN: 1477-111X [Electronic] England
• PMID: 30938270 (Publication Type: Journal Article)

Chemical References

• Bicarbonates
• Carbon Dioxide

Topics

• Animals
• Bicarbonates (blood)
• Carbon Dioxide (blood)
• Extracorporeal Circulation (methods)
• Humans
• Male
• Rats
• Rats, Sprague-Dawley
• Renal Dialysis (methods)