Grape-seed extracts contain rich
flavonoids with oligomeric
proanthocyanidins (OPC). In this study, OPC containing
hydrogel scaffolds can function as a natural photothermal agent for
melanoma therapy and bioactive
biomaterial for wound healing. Inspired by grape-seed extracts, OPC were explored as a photothermal agent and endowed the
hydrogel scaffolds with excellent and controlled photothermal ability. The rheological property of the
hydrogel scaffolds responded to irradiation time of near infrared (NIR)
laser, and OPC contents. The compressive mechanical property of the
hydrogel scaffolds was well modulated by NIR
laser irradiation with different impact durations. The controlled high temperature induced by OPC-containing
hydrogel scaffolds under NIR
laser irradiation could effectively kill
melanoma cells and suppress
tumor growth. In addition, OPC-containing
hydrogel scaffolds supported the proliferation and migration of human dermal fibroblasts and human umbilical vein endothelial cells, as well as obviously promoted angiogenesis and skin regeneration in both
tumor-caused and chronic
wounds. Therefore, OPC-containing
hydrogel scaffolds possessed controlled photothermal, rheological, and compressive mechanical properties under NIR
laser stimuli, as well as excellent biocompatibility and bioactivity for
melanoma therapy and wound healing.