Abstract | BACKGROUND: METHODS: This study included 308 patients whose muscle strength and mass had been evaluated using handgrip strength and dual-energy X-ray absorptiometry, respectively. Sarcopenia was defined according to the criteria established by the Asian Working Group on Sarcopenia. In addition, this cohort had been followed up for 9 years. RESULTS: The prevalence of sarcopenia was 40% (37% in males and 45% in females) with gender differences being insignificant (p = 0.237). The DM morbidity rate was significantly higher in those with sarcopenia than in those without sarcopenia (41% vs. 27%, p = 0.015). Multivariate regression analyses showed that the presence of DM was an independent contributor to sarcopenia in patients undergoing HD (odds ratio 3.11; 95% confidence interval 1.63-5.93; p < 0.001). During the follow-up of 76 ± 35 months, 100 patients died. Patients with sarcopenia demonstrated significantly higher rates of all-cause mortality than those without sarcopenia (p < 0.001 using the log-rank test). Multivariate Cox proportional hazards analyses revealed that the presence of DM was significantly associated with higher all-cause mortality (adjusted hazard ratio: 2.39; 95% confidence interval 1.51-3.81; p < 0.001). CONCLUSIONS: The prevalence of sarcopenia among this cohort of patients undergoing HD was determined to be 40%. Moreover, the presence of DM was an independent contributor to sarcopenia and an independent predictor of all-cause mortality in this population.
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Authors | Katsuhito Mori, Kozo Nishide, Senji Okuno, Tetsuo Shoji, Masanori Emoto, Akihiro Tsuda, Shinya Nakatani, Yasuo Imanishi, Eiji Ishimura, Tomoyuki Yamakawa, Shigeichi Shoji, Masaaki Inaba |
Journal | BMC nephrology
(BMC Nephrol)
Vol. 20
Issue 1
Pg. 105
(03 28 2019)
ISSN: 1471-2369 [Electronic] England |
PMID | 30922266
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Cohort Studies
- Diabetes Mellitus
(diagnosis, mortality)
- Female
- Follow-Up Studies
- Hand Strength
(physiology)
- Humans
- Male
- Middle Aged
- Mortality
(trends)
- Muscle Strength
(physiology)
- Renal Dialysis
(adverse effects, trends)
- Renal Insufficiency, Chronic
(diagnosis, mortality, therapy)
- Sarcopenia
(diagnosis, mortality)
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