The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.

Abstract

OBJECTIVES:

Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation (VDS) on mediators of systemic inflammation in dark-skinned, periodontitis patients.

MATERIALS AND METHODS:

A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or placebo group and received intensive single visit scaling and root planning to elicit a systemic inflammatory response.

RESULTS:

Vitamin D supplementation increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs.

CONCLUSION:

In conclusion, VDS has multiple benefits for reducing systemic inflammation and promoting induction of autophagy-related proteins related to anti-microbial functions.

• Authors: Mohamed M Meghil, Lance Hutchens, Anas Raed, Neha A Multani, Mythilypriya Rajendran, Haidong Zhu, Stephen Looney, Mahmoud Elashiry, Roger M Arce, Mark E Peacock, Yanbin Dong, Christopher W Cutler
• Journal: Oral diseases (Oral Dis) Vol. 25 Issue 5 Pg. 1403-1413 (Jul 2019) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 30912231 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

Chemical References

• Inflammation Mediators
• Vitamins
• Vitamin D

Topics

• Dietary Supplements
• Humans
• Inflammation (blood, etiology)
• Inflammation Mediators (blood)
• Periodontitis
• Pilot Projects
• Vitamin D (administration & dosage, therapeutic use)
• Vitamin D Deficiency (blood, complications, immunology)
• Vitamins (therapeutic use)